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Rabbit Anti-SMPD2 Recombinant Antibody (CBWJN-1680) (CBMAB-N4306-WJ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJN-1680
Antibody Isotype
IgG
Application
WB, IP, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Introduction
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Entrez Gene ID
Human6610
Mouse20598
Rat83537
UniProt ID
HumanO60906
MouseO70572
RatQ9ET64
Alternative Names
Sphingomyelin Phosphodiesterase 2; Neutral Sphingomyelinase; Lyso-Platelet-Activating Factor-Phospholipase C; Lyso-PAF-PLC; N-SMase; NSMASE;
Function
Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884).
Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884).
Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383).
Biological Process
Biological Process ceramide biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingolipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingomyelin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sphingomyelin metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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