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Mouse Anti-SMOX Recombinant Antibody (CBXS-0571) (CBMAB-S3513-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0571
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Spermine Oxidase
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermine Oxidase
Introduction
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
Entrez Gene ID
54498
UniProt ID
Q9NWM0
Alternative Names
Spermine Oxidase; Polyamine Oxidase 1; C20orf16; PAOH1; PAO-1; SMO; Putative Cyclin G1 Interacting Protein; Chromosome 20 Open Reading Frame 16;
Function
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N1-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Biological Process
Biological Process polyamine biosynthetic processTAS:Reactome
Biological Process polyamine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spermine catabolic processIDA:UniProtKB
Biological Process xenobiotic metabolic processTAS:Reactome
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Isoform 4
Cytoplasm
Nucleus
Isoform 6
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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