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Mouse Anti-SLC5A2 Recombinant Antibody (3G8) (CBMAB-A8249-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC5A2 (NP_003032.1, 228 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 2
Introduction
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq]
Entrez Gene ID
6524
UniProt ID
P31639
Alternative Names
SGLT2
Function
Electrogenic Na+-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump (PubMed:20980548, PubMed:28592437, PubMed:34880493).
Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
Biological Process
Biological Process alpha-glucoside transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glucose import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process hexose transmembrane transportTAS:Reactome
Biological Process renal glucose absorptionISS:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Apical cell membrane
Involvement in disease
Renal glucosuria (GLYS):
A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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