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Mouse Anti-SLC40A1 Monoclonal Antibody (Y33C) (CBMAB-1243-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
Y33C
Antibody Isotype
IgG
Application
ELISA, FC, ICC, IF, IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Trp127-Val321
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 40 Member 1
Introduction
SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in SLC40A1 gene are a cause of hemochromatosis type 4 (HFE4).
Entrez Gene ID
30061
UniProt ID
Q9NP59
Alternative Names
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3
Function
Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071).
Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity).
Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity).
When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).
Biological Process
Biological Process apoptotic processIEA:Ensembl
Biological Process cellular iron ion homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endothelium developmentIEA:Ensembl
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process iron ion export across plasma membraneISS:ARUK-UCL
Biological Process iron ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iron ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process multicellular organismal iron ion homeostasisISS:BHF-UCL
Biological Process negative regulation of apoptotic processIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription from RNA polymerase II promoter in response to ironIEA:Ensembl
Biological Process spleen trabecula formationIEA:Ensembl
Biological Process transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Cell membrane
Localized to the basolateral membrane of polarized epithelial cells.
Involvement in disease
Hemochromatosis 4 (HFE4):
A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
PTM
Polyubiquitinated by RNF217; leading to proteasomal degradation. Ubiquitination is necessary for its internalization by hepcidin/HAMP (PubMed:22682227).
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For research use only. Not intended for any clinical use.

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