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Mouse Anti-SLC32A1 (AA 2-133) Recombinant Antibody (CBXS-3695) (CBMAB-S0970-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3695
Antibody Isotype
IgG1
Application
ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-133

Target

Full Name
Solute Carrier Family 32 Member 1
Introduction
The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.
Entrez Gene ID
140679
UniProt ID
Q9H598
Alternative Names
Solute Carrier Family 32 Member 1; Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1; Vesicular Inhibitory Amino Acid Transporter; GABA And Glycine Transporter; Vesicular GABA Transporter; HVIAAT; VIAAT; VGAT;
Function
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity).
May also transport beta-alanine (By similarity).
Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).
Biological Process
Biological Process agingIEA:Ensembl
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process beta-alanine transportISS:UniProtKB
Biological Process gamma-aminobutyric acid importISS:UniProtKB
Biological Process gamma-aminobutyric acid transportISS:UniProtKB
Biological Process glycine transportISS:UniProtKB
Biological Process hippocampus developmentIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter secretionTAS:Reactome
Cellular Location
Cytoplasmic vesicle membrane
Presynapse
Presents in glycine-, GABA- or GABA- and glycine-containing boutons.
Topology
Cytoplasmic: 1-132
Helical: 133-153
Lumenal: 154-204
Helical: 205-225
Cytoplasmic: 226-265
Helical: 266-286
Lumenal: 287-305
Helical: 306-326
Cytoplasmic: 327-341
Helical: 342-362
Lumenal: 363-383
Helical: 384-404
Cytoplasmic: 405-438
Helical: 439-459
Lumenal: 460-461
Helical: 462-482
Cytoplasmic: 483-489
Helical: 490-510
Lumenal: 490-510
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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