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Mouse Anti-SLC30A9 Monoclonal Antibody (1C3) (CBMAB-0112-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C3
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SLC30A9
Introduction
SLC30A9 is a protein-coding gene. Diseases associated with SLC30A9 include Birk-Landau-Perez Syndrome. Among its related pathways are Metal ion SLC transporters. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity. SLC30A9 is ubiquitously expressed with high levels in cerebellum, skeletal muscle, thymus and kidney. SLC30A9 encodes a putative zinc transporter previously associated with Wnt signalling.
Entrez Gene ID
10463
UniProt ID
Q6PML9
Alternative Names
C4orf1; GAC63; HUEL; ZNT9
Function
Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855).
Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity).
Biological Process
Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process nucleotide-excision repairManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Nucleus
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Mainly in the cytoplasm (PubMed:10409434).
Partial co-localization with endoplasmic reticulum (PubMed:28334855).
Involvement in disease
Birk-Landau-Perez syndrome (BILAPES):
An autosomal recessive syndrome characterized by early-childhood onset of different combinations of intellectual disability, muscle weakness, camptocormia, oculomotor apraxia, and nephropathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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