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Mouse Anti-SLC12A1 Recombinant Antibody (CPTC-SLC12A1-1) (CBMAB-0563-LY)


See all SLC12A1 antibodies
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Summary

Host Animal
Mouse
Specificity
Human, Frog
Antibody Isotype
IgG1
Application
FFPE, IF, IHC, IP, WB

Basic Information

Immunogen
Human NKCC1 C-terminus (Met902-Ser1212)
Specificity
Human, Frog
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Solute Carrier Family 12 Member 1
Introduction
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Entrez Gene ID
6557
UniProt ID
P55011
Alternative Names
NKCC1
Function
Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.
Biological Process
Biological Process cell volume homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transmembrane transportISS:BHF-UCL
Biological Process ion transportTAS:Reactome
Biological Process potassium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Apical cell membrane
Involvement in disease
Bartter syndrome 1, antenatal (BARTS1):
A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
Topology
Cytoplasmic: 1-177
Helical: 178-198
Extracellular: 202-222
Helical: 223-259
Cytoplasmic: 260-280
Helical: 303-323
Extracellular: 324-327
Helical: 328-348
Cytoplasmic: 380-400
Helical: 401-417
Extracellular: 418-438
Helical: 485-505
Cytoplasmic: 506-550
Helical: 551-571
Extracellular: 572-592
Helical: 593-609
Cytoplasmic: 610-630
Helical: 793-813
Extracellular: 814-1099
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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