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Mouse Anti-SLC10A1 Antibody (C3B6) (CBMAB-1583CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C3B6
Antibody Isotype
IgG1, κ
Application
FC, IHC

Basic Information

Immunogen
Peptide (YSRGIYDGDLKDKVPY)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLC10A1
Introduction
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Diseases associated with SLC10A1 include Biliary Atresia and Hepatitis B. Among its related pathways are Hepatic ABC Transporters and Metabolism.
Entrez Gene ID
6554
UniProt ID
Q14973
Alternative Names
NTCP; Growth-Inhibiting Protein 29; Na(+)/Taurocholate Transport Protein
Function
As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352).
It is strictly dependent on the extracellular presence of sodium (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352).
It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352).
Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).
(Microbial infection) Acts as a receptor for hepatitis B virus.
Biological Process
Biological Process bile acid and bile salt transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process bile acid signaling pathwayIEA:Ensembl
Biological Process cellular response to xenobiotic stimulusIEA:Ensembl
Biological Process regulation of bile acid secretionIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl
Biological Process response to 17alpha-ethynylestradiolIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Hypercholanemia, familial, 2 (FHCA2):
An autosomal recessive inborn error of metabolism characterized by persistently increased plasma levels of conjugated bile salts apparent from infancy, fat malabsorption and impaired absorption of fat-soluble vitamins, including D and K. Most patients are asymptomatic. Some neonates may have transient jaundice or transiently elevated liver enzymes.
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For research use only. Not intended for any clinical use.

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