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Rabbit Anti-SIRT3 Recombinant Antibody (CBXS-6171) (CBMAB-S6387-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
CBXS-6171
Antibody Isotype
IgG
Application
IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to the sequence of human SirT3 protein
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.01 M HEPES, 0.15 M NaCl, 0.1 mg/mL BSA, 50% glycerol, pH 7.5
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SIRT3
Introduction
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
Entrez Gene ID
Human23410
Rat293615
UniProt ID
HumanQ9NTG7
MonkeyF6TH81
RatB2RZ31
Alternative Names
Sirtuin 3; Regulatory Protein SIR2 Homolog 3; SIR2-Like Protein 3; SIR2L3; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae); Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3; Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase; Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3;
Function
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).
Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).
Important for regulating tissue-specific ATP levels (PubMed:18794531).
In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
Biological Process
Biological Process aerobic respirationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine deacetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of catalase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of ceramide biosynthetic processISS:UniProtKB
Biological Process positive regulation of superoxide dismutase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process protein ADP-ribosylationBy SimilarityISS:GO_Central
Biological Process protein deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion matrix
PTM
Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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