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Rabbit Anti-SIGIRR Recombinant Antibody (CBXS-1079) (CBMAB-S3968-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1079
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Human SIGIRR/TIR8 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Single Ig And TIR Domain Containing
Entrez Gene ID
59307
UniProt ID
Q6IA17
Alternative Names
Single Ig And TIR Domain Containing; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain; Single Immunoglobulin Domain-Containing IL1R-Related Protein; Single Immunoglobulin Domain IL1R1 Related; Single Ig IL-1R-Related Molecule; Toll/Interleukin-1 Receptor 8;
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Biological Process
Biological Process acute-phase responseISS:HGNC-UCL
Biological Process negative regulation of chemokine productionISS:HGNC-UCL
Biological Process negative regulation of cytokine-mediated signaling pathwayISS:HGNC-UCL
Biological Process negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process negative regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process signal transductionIEA:InterPro
Cellular Location
Membrane
Topology
Extracellular: 1-118
Helical: 119-139
Cytoplasmic: 140-410
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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