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Mouse Anti-SHANK1 Recombinant Antibody (S22-21) (CBMAB-S0009-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S22-21
Antibody Isotype
IgG1
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 and multiple ankyrin repeat domains 1
Introduction
This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males.
Entrez Gene ID
Human50944
Mouse243961
Rat78957
UniProt ID
HumanQ9Y566
MouseD3YZU1
RatQ9WV48
Alternative Names
SH3 And Multiple Ankyrin Repeat Domains 1; Somatostatin Receptor-Interacting Protein; SSTR-Interacting Protein; SSTRIP; SH3 And Multiple Ankyrin Repeat Domains Protein 1; SPANK-1; Synamon; Shank1;
Function
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Biological Process
Biological Process adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process associative learningISS:BHF-UCL
Biological Process dendritic spine morphogenesisISS:BHF-UCL
Biological Process determination of affectManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process habituationIEA:Ensembl
Biological Process long-term memoryISS:BHF-UCL
Biological Process negative regulation of actin filament bundle assemblyISS:BHF-UCL
Biological Process neuromuscular process controlling balanceISS:BHF-UCL
Biological Process olfactory behaviorIEA:Ensembl
Biological Process positive regulation of dendritic spine developmentISS:BHF-UCL
Biological Process positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Biological Process protein localization to synapseISS:BHF-UCL
Biological Process protein-containing complex assemblyISS:BHF-UCL
Biological Process regulation of AMPA receptor activityISS:BHF-UCL
Biological Process righting reflexIEA:Ensembl
Biological Process social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process synapse maturationISS:BHF-UCL
Biological Process vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cytoplasm
Postsynaptic density
Synapse
Colocalizes with alpha-latrotoxin receptor 1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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