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Mouse Anti-SH2D1A Recombinant Antibody (CBXS-3948) (CBMAB-S1211-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3948
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH2D1A
Introduction
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
4068
UniProt ID
O60880
Alternative Names
SH2 Domain Containing 1A; Signaling Lymphocytic Activation Molecule-Associated Protein; Duncan Disease SH2-Protein; SLAM-Associated Protein; DSHP; SAP; Signaling Lymphocyte Activation Molecule-Associated Protein; SLAM Associated Protein/SH2 Domain Protein 1A; T Cell Signal Transduction Molecule SAP; T-Cell Signal Transduction Molecule SAP; SH2 Domain-Containing Protein 1A; Lymphoproliferative Syndrome;
Function
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999).
However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214).
Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity).
May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell-cell signalingIEA:InterPro
Biological Process cellular defense responseIEA:InterPro
Biological Process humoral immune responseIEA:Ensembl
Biological Process natural killer cell mediated cytotoxicityIEA:Ensembl
Biological Process negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Involvement in disease
Lymphoproliferative syndrome, X-linked, 1 (XLP1):
A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
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For research use only. Not intended for any clinical use.

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