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Mouse Anti-SESN2 Recombinant Antibody (CBXS-4784) (CBMAB-S2010-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Cat
Clone
CBXS-4784
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
SESN2 (AAH13304, 1 a.a.-481 a.a) full length recombinant protein
Specificity
Human, Cat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sestrin 2
Introduction
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
Entrez Gene ID
Human83667
Cat101091128
UniProt ID
HumanP58004
CatA0A5F5XNP8
Alternative Names
Sestrin 2; SEST2; HI95; Hypoxia Induced Gene 95; Hypoxia-Induced Gene; Hypoxia-Induced; EC 1.11.1.15; Sestrin-2; Ses2;
Function
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100).
In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100).
Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100).
This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615).
May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085).
May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468).
Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684).
Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503).
However, this could not be confirmed (PubMed:19113821).
Biological Process
Biological Process cellular oxidant detoxificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucineManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to oxidative stressISS:UniProtKB
Biological Process DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process fatty acid beta-oxidationIEA:Ensembl
Biological Process glucose homeostasisIEA:Ensembl
Biological Process glucose importIEA:Ensembl
Biological Process mitochondrial DNA metabolic processIEA:Ensembl
Biological Process negative regulation of cell growthISS:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of translation in response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of lipophagyIEA:Ensembl
Biological Process positive regulation of macroautophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein kinase B signalingIEA:Ensembl
Biological Process reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cAMP-dependent protein kinase activityIEA:Ensembl
Biological Process regulation of gluconeogenesisIEA:Ensembl
Biological Process regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of response to reactive oxygen speciesIEA:InterPro
Biological Process response to glucoseIEA:Ensembl
Biological Process response to insulinIEA:Ensembl
Biological Process triglyceride homeostasisIEA:Ensembl
Cellular Location
Cytoplasm
PTM
Phosphorylated by ULK1 at multiple sites.
Ubiquitinated at Lys-175 by RNF167 via 'Lys-63'-linked polyubiquitination in response to leucine deprivation: ubiquitination promotes SESN2-interaction with the GATOR2 complex, leading to inhibit the TORC1 signaling pathway (PubMed:35114100).
Deubiquitinated at Lys-175 by STAMBPL1, promoting the TORC1 signaling pathway (PubMed:35114100).
Ubiquitinated by RNF186; ubiquitination mediates proteasomal degradation (PubMed:31586034).
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For research use only. Not intended for any clinical use.

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