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Mouse Anti-SERBP1 Recombinant Antibody (CBXS-5768) (CBMAB-S0628-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5768
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-262 of human SERBP1 (NP_001018078) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SERPINE1 mRNA binding protein 1
Introduction
SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer. Gene Ontology (GO) annotations related to this gene include mRNA 3-UTR binding. An important paralog of this gene is HABP4.
Entrez Gene ID
26135
UniProt ID
Q8NC51
Alternative Names
SERPINE1 MRNA Binding Protein 1; PAI1 RNA-Binding Protein 1; PAI-RBP1; PAIRBP1; Chromodomain Helicase DNA Binding Protein 3 Interacting Protein; Plasminogen Activator Inhibitor 1 RNA-Binding Protein;
Function
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Biological Process
Biological Process PML body organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of mRNA stability1 PublicationNAS:HGNC-UCL
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, perinuclear region
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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