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Rat Anti-SEMA6C Recombinant Antibody (CBXS-1740) (CBMAB-S4566-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-1740
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
NS0-derived recombinant mouse Semaphorin 6C, Ala26-Ile602, Accession # Q9WTM3
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Introduction
This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.
Entrez Gene ID
20360
UniProt ID
E9Q613
Alternative Names
Semay; mKIAA1869
Function
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extensionIDA:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 25-604
Helical: 605-625
Cytoplasmic: 626-930
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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