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Rat Anti-SELL Recombinant Antibody (MAB0824) (CBMAB-C12389-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
MAB0824
Antibody Isotype
IgG2
Application
FC

Basic Information

Immunogen
Mouse B lymphoma
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Selectin L
Introduction
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Entrez Gene ID
20343
UniProt ID
P18337
Alternative Names
Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1;
Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Biological Process
Biological Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 39-332
Helical: 333-355
Cytoplasmic: 356-372
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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