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Mouse Anti-SAT1 Antibody (11BA19) (CBMAB-1549CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
11BA19
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermidine/Spermine N1-Acetyltransferase 1
Introduction
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Diseases associated with SAT1 include Keratosis Follicularis Spinulosa Decalvans, X-Linked and Keratosis Follicularis Spinulosa Decalvans. Among its related pathways are Metabolism and spermine and spermidine degradation I.
Entrez Gene ID
6303
UniProt ID
Q9H2B4
Alternative Names
SAT1; SAT; SAT-1; SSAT; SSAT-1; DC21; KFSD
Function
Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632).
Substrate specificity: norspermidine = spermidine>> spermine> N1-acetylspermine (PubMed:17516632).
This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797).
Also involved in the regulation of polyamine transport out of cells (PubMed:16455797).
Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632).
Biological Process
Biological Process angiogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process polyamine biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process putrescine catabolic processIEA:UniProtKB-UniPathway
Biological Process spermidine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Overexpression of SAT1 and the consequent putrescine accumulation might play a role in the pathogenesis of keratosis follicularis spinulosa decalvans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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