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Mouse Anti-SARS-CoV Nucleoprotein Recombinant Antibody (CBMC-C0006) (CBMAB-V208-0146-CQ)


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Summary

Host Animal
Mouse
Specificity
SARS-CoV
Clone
CBMC-C0006
Antibody Isotype
IgG1
Application
ELISA, IHC, FC, IF

Basic Information

Immunogen
Recombinant Human SARS Coronavirus Nucleoprotein / NP Protein
Specificity
SARS-CoV
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Human SARS coronavirus Nucleoprotein
Introduction
Nucleoproteins are any proteins that are structurally associated with nucleic acids, either DNA or RNA. Typical nucleoproteines include ribosomes, nucleosomes, and viral nucleocapsid proteins.
Alternative Names
SARS-CoV Nucleoprotein
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170).
May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).
Biological Process
Viral RNA genome packaging
Cellular Location
Virion
Host endoplasmic reticulum-Golgi intermediate compartment
Host Golgi apparatus
Host cytoplasm, host perinuclear region
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
PTM
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues (By similarity).
Phosphorylated by host GSK3A and GSK3B. Phosphorylation allows recruitment of host RNA helicase DDX1 which facilitates template readthrough and enables longer subgenomic mRNA synthesis
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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