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Human Anti-SARS-CoV-2 N Monoclonal Antibody (CBFYR-0118) (CBMAB-R0118-FY)


See all SARS-CoV-2 N antibodies
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Tested Data
Fig.1 Response curve of CBMAB-R0118-FY against SARS-CoV-2 N.
Fig.1 Western Blot analysis of CBMAB-R0118-FY.

Summary

Host Animal
Human
Specificity
2019 Novel Coronavirus
Clone
CBFYR-0118
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
2019 Novel Coronavirus
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SARS-CoV-2 N
Introduction
The newly identified 2019 novel coronavirus (SARS-CoV-2) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health.
Alternative Names
SARS-CoV-2 N; 2019 Novel Coronavirus Nucleocapsid Protein
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity).
May induce inflammasome responses in cultured cells and mice. Acts by interacting with host NLRP3 to facilitate inflammasome assembly, which induces cytokine release that may play a role in COVID lung injury.
Biological Process
Biological Process negative regulation of interferon-beta productionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of NLRP3 inflammasome complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to host immune responseManual Assertion Based On ExperimentIDA:DisProt
Biological Process viral RNA genome packaging1 PublicationIC:ComplexPortal
Cellular Location
Virion
Host cytoplasm
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
PTM
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine residues by host GSK3A and GSK3B.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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