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Rabbit Anti-S100P Recombinant Antibody (CBXS-4256) (CBMAB-S1508-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-4256
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Human S100P Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
S100 Calcium Binding Protein P
Introduction
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
Entrez Gene ID
6286
UniProt ID
P25815
Alternative Names
S100 Calcium Binding Protein P; Migration-Inducing Gene 9 Protein; S100 Calcium-Binding Protein P; Protein S100-E; MIG9; Protein S100-P; S100E;
Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Biological Process
Biological Process endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to organic substanceManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell projection, microvillus membrane
Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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