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Recombinant Mouse Anti-RXRg Recombinant Antibody (12RX-2D3) (CBMAB-XB1013-YC)


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Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
12RX-2D3
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Synthetic peptide RSRERAESEAECA. Epitope corresponds to aa 215-227 (D-region) of mouse RXRg.
Specificity
Mouse, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Retinoid X Receptor Gamma
Introduction
RXRg is a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements.
Entrez Gene ID
Human6258
Mouse20183
UniProt ID
HumanP48443
MouseP28705
Alternative Names
Retinoid X Receptor Gamma; Nuclear Receptor Subfamily 2 Group B Member 3; NR2B3; Retinoic Acid Receptor RXR-Gamma; Retinoid X Receptor, Gamma; RXRC;
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Biological Process
Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentIEA:Ensembl
Biological Process neuron differentiationIEA:Ensembl
Biological Process peripheral nervous system developmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of myelinationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to retinoic acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle tissue developmentIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Acetylated by EP300.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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