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Mouse Anti-RRP9 Recombinant Antibody (CBCNR-818) (CBMAB-R3710-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-818
Antibody Isotype
IgG2b
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Ribosomal RNA Processing 9, U3 Small Nucleolar RNA Binding Protein
Introduction
This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
Entrez Gene ID
9136
UniProt ID
O43818
Alternative Names
Ribosomal RNA Processing 9, U3 Small Nucleolar RNA Binding Protein; U3 Small Nucleolar Ribonucleoprotein-Associated 55 KDa Protein; RNA, U3 Small Nucleolar Interacting Protein 2; RRP9 Homolog; RNU3IP2; U3-55K; Ribosomal RNA Processing 9, Small Subunit (SSU) Processome Component, Homolog (Yeast);
Function
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA).
Biological Process
rRNA processing
Cellular Location
Nucleus, nucleolus
PTM
Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678).
Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing (PubMed:26867678).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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