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Mouse Anti-RRP9 Recombinant Antibody (1E8) (CBMAB-A7688-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E8
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
RNU3IP2 (AAH01113, 1 a.a. ~ 475 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ribosomal RNA Processing 9, U3 Small Nucleolar RNA Binding Protein
Entrez Gene ID
9136
UniProt ID
O43818
Alternative Names
RNU3IP2; U3-55K
Function
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA).
Biological Process
rRNA processing
Cellular Location
Nucleus, nucleolus
PTM
Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678).
Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing (PubMed:26867678).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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