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Mouse Anti-RPRD1A Recombinant Antibody (1B8) (CBMAB-P3614-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1B8
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa76-171 from human P15RS (NP_060640) with GST tag.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RPRD1A
Introduction
RPRD1A is a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo-and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. A pseudogene of this gene is found on chromosome 16.
Entrez Gene ID
Human55197
Mouse225283
Rat291736
UniProt ID
HumanQ96P16
MouseQ8VDS4
RatD4AAU4
Alternative Names
Regulation Of Nuclear Pre-MRNA Domain Containing 1A; Cyclin-Dependent Kinase Inhibitor 2B-Related Protein (P15INK4B-Related Protein); Cyclin-Dependent Kinase 2B-Inhibitor-Related Protein; P15INK4B-Related Protein; P15RS; Regulation Of Nuclear Pre-MRNA Domain-Containing Protein 1A; Cyclin-Dependent Kinase Inhibitor 2B-Related Protein; CDKN2B-Related Protein; HsT3101;
Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Biological Process
Biological Process dephosphorylation of RNA polymerase II C-terminal domainManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA 3'-end processingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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