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Mouse Anti-ROBO3 Recombinant Antibody (15H2) (CBMAB-0040-CN)


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Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
15H2
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Drosophila protein made in E. coli.
Specificity
Common fruit fly
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Introduction
The Roundabout genes encode transmembrane receptors that mediate repulsive cues by binding to midline repellent sli and regulate axon guidance.
Entrez Gene ID
33314
UniProt ID
Q9VPZ7
Alternative Names
CG14345; CG5423; CT17158; Dmel\CG5423; dRobo-3; Robo 3; Robo-3; Robo3; ROBO3
Function
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity).
In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity).
Required for hindbrain axon midline crossing (PubMed:15105459).
Biological Process
Biological Process axon guidanceISS:UniProtKB
Biological Process axon midline choice point recognitionISS:UniProtKB
Biological Process dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Involvement in disease
Gaze palsy, familial horizontal, with progressive scoliosis, 1 (HGPPS1):
An autosomal recessive neurologic disorder characterized by eye movement abnormalities apparent from birth, childhood-onset progressive scoliosis, distinctive brainstem malformation and defective crossing of some brainstem neuronal pathways.
Topology
Extracellular: 21-891
Helical: 892-912
Cytoplasmic: 913-1386
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For research use only. Not intended for any clinical use.

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