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Mouse Anti-RBFOX3 Recombinant Antibody (1B7) (CBMAB-1754-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Goat, Chicken, Cattle, Cat, Dog, Pig, Sea urchin, Common marmoset
Clone
1B7
Antibody Isotype
IgG2a, Κ
Application
IF, IHC-P, WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human NeuN aa. 1-100 (N terminal). Expressed in and purified from E. coli. Sequence: MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHGMTLYTP AQTHPEQPGSEASTQPIAGTQTVPQTDEAAQTDSQPLHPSDPTEKQQPKREASTQPIAGTQTVPQTDEAAQTDSQPLHPSDPTEKQQPKR
Specificity
Human, Mouse, Rat, Goat, Chicken, Cattle, Cat, Dog, Pig, Sea urchin, Common marmoset
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
10mM Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA Binding Fox-1 Homolog 3
Introduction
This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. Mutations in this gene have been associated with numerous neurological disorders. It regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
Entrez Gene ID
Human146713
Mouse52897
Rat287847
Cattle511773
Pig110256156
Goat102186905
Chicken100857589
Cat101084840
Dog608803
UniProt ID
HumanA6NFN3
MouseQ8BIF2
RatD4A2H6
CattleQ0VD23
PigA0A286ZN97
GoatA0A452DZ45
ChickenT1P465
CatM3VYQ8
DogJ9PAH3
Alternative Names
FOX3; NEUN; FOX-3; HRNBP3
Function
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
Biological Process
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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