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Rabbit Anti-PYY Recombinant Antibody (D1K3Q) (CBMAB-CP2151-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
D1K3Q
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly37 of mouse PYY protein. Please note that Gly37 corresponds to Gly9 and Gly7 of PYY (1-36) and PYY (3-36), respectively.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
peptide YY
Introduction
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa.
Entrez Gene ID
217212
UniProt ID
Q9EPS2
Function
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Biological Process
Biological Process feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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