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Rabbit Anti-PTGFR Recombinant Antibody (BA0294) (CBMAB-0743CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0294
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from C terminal residues of Human Prostaglandin F2 alpha Receptor
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Prostaglandin F receptor
Introduction
The protein encoded by this gene is member of the G-protein coupled receptor family. Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Entrez Gene ID
5737
UniProt ID
P43088
Alternative Names
FP
Function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).
Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Calcium-mediated signaling using intracellular calcium sourceManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to prostaglandin D stimulusManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
ParturitionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-69
Helical: 70-90
Extracellular: 91-109
Helical: 110-131
Cytoplasmic: 132-152
Helical: 153-175
Extracellular: 176-198
Helical: 199-224
Cytoplasmic: 225-250
Helical: 251-267
Extracellular: 268-285
Helical: 286-307
Cytoplasmic: 308-359
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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