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Mouse Anti-PSPH Recombinant Antibody (CBYC-P732) (CBMAB-P3275-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYC-P732
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant human PSP (1-225aa) purified from E. coli
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 0.1% sodium azide, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphoserine phosphatase
Introduction
PSPH belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.
Entrez Gene ID
Human5723
Mouse100678
UniProt ID
HumanP78330
MouseQ99LS3
Alternative Names
PSPHD; PSP
Function
Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166).
L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469).
May also act on O-phospho-D-serine (Probable).
Biological Process
DephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
In utero embryonic developmentIEA:Ensembl
L-serine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to mechanical stimulusIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to testosteroneIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Phosphoserine phosphatase deficiency (PSPHD):
An autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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