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Rabbit Anti-PSMC5 Recombinant Antibody (CBYC-P709) (CBMAB-P3208-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYC-P709
Antibody Isotype
IgG
Application
WB, IP, IHC-P, FC, ICC, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome 26S Subunit, ATPase 5
Introduction
PSMC5 (Proteasome 26S Subunit, ATPase 5) is a protein coding gene. Diseases associated with PSMC5 include Mulibrey Nanism and Ogden Syndrome. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include signaling receptor binding and transcription factor binding.
Entrez Gene ID
Human5705
Mouse19184
Rat81827
UniProt ID
HumanP62195
MouseP62196
RatP62198
Alternative Names
mSUG1
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Biological Process
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of programmed cell death1 PublicationNAS:UniProtKB
Negative regulation of transcription, DNA-templatedIEA:Ensembl
Positive regulation of inclusion body assemblyIEA:Ensembl
Positive regulation of proteasomal protein catabolic process1 PublicationIC:UniProtKB
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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