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Mouse Anti-PRMT6 Monoclonal Antibody (2C9) (CBMAB-0010-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2C9
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein arginine methyltransferase 6
Introduction
The gene encodes a protein whch belong to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine.
Entrez Gene ID
55170
UniProt ID
Q96LA8
Alternative Names
FLJ10559; HRMT1L6
Function
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520).
Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910).
Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460).
H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460).
Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293).
Repression of TP53 blocks cellular senescence (By similarity).
Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869).
Methylates HMGA1 (PubMed:16157300, PubMed:16159886).
Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity).
May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505).
Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity).
Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520).
Biological Process
Base-excision repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular senescenceIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Histone H3-R2 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K4 methylationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-arginine methylation, to asymmetrical-dimethyl arginineManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of megakaryocyte differentiationTAS:Reactome
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of signal transduction by p53 class mediatorIEA:Ensembl
Cellular Location
Nucleus
PTM
Automethylation enhances its stability and antiretroviral activity.
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For research use only. Not intended for any clinical use.

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