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Mouse Anti-PRELID1 Monoclonal Antibody (6G1) (CBMAB-1446-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6G1
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein PRELID1 (NP_037369, aa 3-101) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRELI domain containing 1
Introduction
PRELID1 is a member of the late embryogenesis abundant motif-containing protein family which is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation.
Entrez Gene ID
27166
UniProt ID
Q9Y255
Alternative Names
PX19; PRELI; SBBI12; CGI-106
Function
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Intermembrane lipid transferIEA:GOC
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipid transportManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular respirationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phospholipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of membrane lipid distributionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion
Mitochondrion intermembrane space
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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