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Mouse Anti-PRDX3 Recombinant Antibody (4G10) (CBMAB-0695CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G10
Antibody Isotype
IgG1
Application
IHC-P, WB, IP, ELISA, IF

Basic Information

Immunogen
Recombinant human protein, between 63-256 of Peroxiredoxin 3
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRDX3
Introduction
This gene encodes a mitochondrial protein with antioxidant function. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
Entrez Gene ID
10935
UniProt ID
P30048
Alternative Names
AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404).
Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:MGI
Maternal placenta developmentIEA:Ensembl
Mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Myeloid cell differentiationISS:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-cysteine oxidationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIMP:UniProtKB
Response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Response to lipopolysaccharideISS:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion
Cytoplasm
Early endosome
Localizes to early endosomes in a RPS6KC1-dependent manner.
PTM
Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
S-palmitoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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