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Mouse Anti-PPP1R17 Recombinant Antibody (CBLG1-2407) (CBMAB-G6472-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2407
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant (aa1-99) from human C7orf16 (NP_006649) with GST tag. MW of the GST tag alone is 26 KDa.ImmunogenType: Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Protein Phosphatase 1 Regulatory Subunit 17
Introduction
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10842
UniProt ID
O96001
Alternative Names
C7orf16; GSBS
Function
Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.
Biological Process
Central nervous system development1 PublicationNAS:UniProtKB
Intracellular signal transduction1 PublicationNAS:UniProtKB
Regulation of phosphatase activityISS:UniProtKB
PTM
Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).
Substrate for cGMP-dependent protein kinase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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