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Mouse Anti-POU2F2 Recombinant Antibody (IHC642) (CBMAB-MA205-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC642
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
POU class 2 homeobox 2
Introduction
POU2F2 is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters.
Entrez Gene ID
5452
UniProt ID
P09086
Alternative Names
OCT2; OTF2; Oct-2
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290).
Regulates IL6 expression in B cells with POU2AF1 (By similarity).
Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654).
Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874).
Isoform 5
Activates the U2 small nuclear RNA (snRNA) promoter.
Biological Process
Cellular response to virusISS:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-6 productionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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