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Mouse Anti-POMC Recombinant Antibody (57) (CBMAB-0671CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
57
Antibody Isotype
IgG1, κ
Application
ELISA, FC, IF, IHC-P

Basic Information

Immunogen
Synthetic peptide from Human ACTH aa 1-24 (N terminal)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Antibody
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proopiomelanocortin
Introduction
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. Diseases associated with POMC include Obesity, Adrenal Insufficiency, And Red Hair Due To Pomc Deficiency and Obesity. Among its related pathways are G alpha (s) signalling events and Metabolism. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.
Entrez Gene ID
Human5443
Mouse18976
Rat24664
UniProt ID
HumanP01189
MouseP01193
RatP01194
Alternative Names
Proopiomelanocortin; Opiomelanocortin Prepropeptide; Adrenocorticotropic Hormone; Adrenocorticotropin; Beta-Endorphin; Corticotropin-Like Intermediary Peptide; Alpha-Melanocyte Stimulating Hormone; Alpha-Melanocyte-Stimulating Hormone; Beta-Melanocyte Stimulating Hormone; Beta-Melanocyte-Stimulating Hormone; Proopiomelanocortin Preproprotein; Melanotropin Alpha; Melanotropin Gamma; Pro-ACTH-Endorphin; Melanotropin Beta; Met-Enkephalin; Alpha-MSH; Gamma-LPH; Gamma-MSH; Beta-LPH; Beta-MSH; CLIP; ACTH; LPH; MSH; NPP; POC
Function
Corticotropin
Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta
Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin
Endogenous orexigenic opiate.
Met-enkephalin
Endogenous opiate.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Calcium-mediated signalingISS:ARUK-UCL
Cell-cell signalingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular pigmentationManual Assertion Based On ExperimentIMP:UniProtKB
Generation of precursor metabolites and energyManual Assertion Based On ExperimentIMP:UniProtKB
Glucose homeostasisIEA:Ensembl
Killing of cells of another organismIDA:UniProtKB
Modulation of process of another organismIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Positive regulation of cAMP-mediated signalingISS:ARUK-UCL
Positive regulation of neutrophil mediated killing of fungusIDA:UniProtKB
Positive regulation of oxytocin productionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of appetiteManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of blood pressureISS:UniProtKB
Regulation of corticosterone secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of glycogen metabolic processIEA:Ensembl
Response to melanocyte-stimulating hormoneISS:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted By Similarity
Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
Involvement in disease
Obesity (OBESITY):
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Obesity, early-onset, with adrenal insufficiency and red hair (OBAIRH):
An autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism.
PTM
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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