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Mouse Anti-PLAUR Recombinant Antibody (CBFYC-3037) (CBMAB-C3114-FY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYC-3037
Antibody Isotype
IgG1, k
Application
WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC

Basic Information

Immunogen
Plasminogen Activator, Urokinase Receptor
Specificity
Rat
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLAUR
Introduction
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix.
Entrez Gene ID
50692
UniProt ID
P49616
Alternative Names
CD87; UPAR; URKR; U-PAR
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of proteolysis1 PublicationNAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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