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Mouse Anti-PLAU Recombinant Antibody (CBXS-5590) (CBMAB-S0468-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5590
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
plasminogen activator, urokinase
Introduction
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Entrez Gene ID
5328
UniProt ID
P00749
Alternative Names
ATF; BDPLT5; QPD; UPA; URK; u-PA
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
FibrinolysisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of fibrinolysis1 PublicationIC:ComplexPortal
Negative regulation of plasminogen activation1 PublicationIC:ComplexPortal
Plasminogen activationManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:MGI
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationIEA:Ensembl
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell-matrix adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of wound healing1 PublicationIC:BHF-UCL
Response to hypoxiaIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Smooth muscle cell migrationIEA:Ensembl
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Quebec platelet disorder (QPD):
An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.
PTM
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
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For research use only. Not intended for any clinical use.

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