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Mouse Anti-PLAGL1 Recombinant Antibody (CBWJZ-005) (CBMAB-Z0011-WJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJZ-005
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
PLAG1 Like Zinc Finger 1
Introduction
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
Entrez Gene ID
Human5325
Mouse22634
Rat25157
UniProt ID
HumanQ9UM63
MouseQ9JLQ4
RatP70616
Alternative Names
ZAC; LOT1; ZAC1
Function
Acts as a transcriptional activator (PubMed:9722527).
Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Diabetes mellitus, transient neonatal, 1 (TNDM1):
An autosomal dominant form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first month of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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