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Mouse Anti-PIH1D1 Recombinant Antibody (4F5-1E10) (CBMAB-P1775-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F5-1E10
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IF, IP, WB

Basic Information

Immunogen
PIH1D1 (AAH01108, 1-290 aa) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PIH1 Domain Containing 1
Introduction
PIH1D1 has ubiquitous expression in placenta (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues.
Entrez Gene ID
55011
UniProt ID
Q9NWS0
Alternative Names
PIH1 Domain Containing 1; Nucleolar Protein 17 Homolog; NOP17; PIH1 Domain-Containing Protein 1;
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026).
Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451).
Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032).
Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).
Biological Process
Box C/D snoRNP assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Chromatin remodelingManual Assertion Based On ExperimentIMP:UniProtKB
Epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Establishment of protein localization to chromatinManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of histone H3-K9 dimethylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of histone H3-K9 trimethylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of histone H4-K16 acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of glucose mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of histone H3-K9 acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of histone H4 acetylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase IManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilization2 PublicationsIC:ComplexPortal
Regulation of histone H3-K4 methylationManual Assertion Based On ExperimentIMP:UniProtKB
rRNA processingManual Assertion Based On ExperimentIBA:GO_Central
SnoRNA localizationManual Assertion Based On ExperimentIMP:UniProtKB
TORC1 complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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