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Mouse Anti-PHM Monoclonal Antibody (3) (CBMAB-1441-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Synthetic human Peptide Histidine Methionine coupled to carrier.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peptide histidine methionine
Introduction
PHM belongs to the glucagon secretin family of peptide hormones and like VIP is a vasodilator and stimulator of intestinal fluid secretion. all pro VIP derived neuropeptides are frequently colocalized, but appear to exert different physiological effects. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine.
Entrez Gene ID
7432
UniProt ID
P01282
Alternative Names
PHM27
Function
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Antibacterial humoral responseIDA:UniProtKB
Antifungal humoral responseIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Body fluid secretionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-negative bacteriumIDA:UniProtKB
Defense response to Gram-positive bacteriumIDA:UniProtKB
Epinephrine secretionManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIDA:UniProtKB
Learning or memoryManual Assertion Based On ExperimentIBA:GO_Central
mRNA stabilizationISS:AgBase
Negative regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of potassium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of epinephrine secretionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of penile erectionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Prolactin secretionISS:AgBase
Regulation of protein localizationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of sensory perception of painManual Assertion Based On ExperimentIBA:GO_Central
Response to yeastIDA:UniProtKB
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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