Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PFKM Recombinant Antibody (CBYC-P311) (CBMAB-P1516-YC)


See all PFKM antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYC-P311
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Phosphofructokinase, Muscle
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphofructokinase, muscle
Introduction
PFKM is a phosphofructokinase isozyme A and may regulate glycolytic flux and influence insulin secretion.
Entrez Gene ID
65152
UniProt ID
P47858
Alternative Names
ATP-PFK; PFK-A; Pfk-M
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Biological Process
Canonical glycolysisManual Assertion Based On ExperimentIBA:GO_Central
Fructose 1,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose 6-phosphate metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Glucose homeostasisIEA:Ensembl
Glycogen catabolic processIEA:Ensembl
Glycolysis from storage polysaccharide through glucose-1-phosphateIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Glycolytic process through fructose-6-phosphateManual Assertion Based On ExperimentIMP:CAFA
Muscle cell cellular homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cytoplasm
Involvement in disease
Glycogen storage disease 7 (GSD7):
A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise.
PTM
GlcNAcylation decreases enzyme activity.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PFKM Recombinant Antibody (CBYC-P311)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry