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Rabbit Anti-PFKM Recombinant Antibody (CBXF-1078) (CBMAB-F1024-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1078
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphofructokinase, muscle
Introduction
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human5213
Mouse18642
Rat65152
UniProt ID
HumanP08237
MouseP47857
RatP47858
Alternative Names
Phosphofructokinase, Muscle; Protein Phosphatase 1, Regulatory Subunit 122; Phosphofructokinase, Polypeptide X; Phosphofructo-1-Kinase Isozyme A; -Phosphofructokinase Type A; Phosphohexokinase; EC 2.7.1.11; ATP-PFK; PFK-A; PFKX; ATP-Dependent 6-Phosphofructokinase, Muscle Type; -Phosphofructokinase, Muscle Type;
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Biological Process
Canonical glycolysisManual Assertion Based On ExperimentIBA:GO_Central
Fructose 1,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose 6-phosphate metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Glucose homeostasisIEA:Ensembl
Glycogen catabolic processIEA:Ensembl
Glycolysis from storage polysaccharide through glucose-1-phosphateIEA:Ensembl
Glycolytic processManual Assertion Based On ExperimentIMP:UniProtKB
Glycolytic process through fructose-6-phosphateManual Assertion Based On ExperimentIMP:CAFA
Muscle cell cellular homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of insulin secretionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cytoplasm
Involvement in disease
Glycogen storage disease 7 (GSD7):
A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise.
PTM
GlcNAcylation decreases enzyme activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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