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Mouse Anti-PENK Recombinant Antibody (9E7) (CBMAB-P1447-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9E7
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PENK (AAH32505, 1-267 aa) full length recombinant protein with GST tag. Immunogen sequence: MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADISFLACVM ECEGKLPSLK IWETCKELLQ LSRPELPQDG TSTLRENSKP EESHLLAKRY GGFMKRYGGF MKKMDELYPM EPEEEANGSE ILAKRYGGFM KKDAEEDDSL ANSSDLLKEL LETGDNRERS HHQDGSDNEE EVSKRYGGFM RGLKRSPQLE DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA LPSDEEGESY SKEVPEMEKR YGGFMRF
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-267

Target

Full Name
proenkephalin
Introduction
PENK is a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu-and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities.
Entrez Gene ID
5179
UniProt ID
P01210
Alternative Names
Proenkephalin; Preproenkephalin; Proenkephalin-A; Enkephalin A; Peptide F; PENK-A; PE;
Function
Met-enkephalin
Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Leu-enkephalin
Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
PENK(114-133)
Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
PENK(237-258)
Increases glutamate release in the striatum.
Biological Process
Aggressive behaviorIEA:Ensembl
AgingIEA:Ensembl
Behavioral fear responseIEA:Ensembl
Cellular response to cAMPIEA:Ensembl
Cellular response to oxidative stressIEA:Ensembl
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
Cellular response to virusIEA:Ensembl
Cellular response to vitamin DIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
General adaptation syndrome, behavioral processIEA:Ensembl
Glial cell proliferationIEA:Ensembl
Locomotory exploration behaviorIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Osteoblast differentiationIEA:Ensembl
Positive regulation of behavioral fear responseIEA:Ensembl
Response to calcium ionIEA:Ensembl
Response to epinephrineIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to morphineIEA:Ensembl
Response to nicotineIEA:Ensembl
Response to radiationIEA:Ensembl
Response to toxic substanceIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentIBA:GO_Central
Sensory perception of painIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Startle responseIEA:Ensembl
Synaptic signaling via neuropeptideIEA:Ensembl
Cellular Location
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen
Secreted
PTM
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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