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Mouse Anti-PDE4C Recombinant Antibody (4E5) (CBMAB-P1216-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E5
Antibody Isotype
IgG3, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PDE4C (NP_000914, 1-99 aa) partial recombinant protein with GST tag. Immunogen sequence: MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQS
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-99

Target

Full Name
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
Introduction
PDE4C belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
5143
UniProt ID
Q08493
Alternative Names
Phosphodiesterase 4C; DPDE1; PDE21; Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1); Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog, Drosophila); Phosphodiesterase E1 Dunce Homolog (Drosophila); CAMP-Specific 3,5-Cyclic Phosphodiesterase 4C;
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell projection, cilium
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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