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Mouse Anti-PAX9 Recombinant Antibody (V2-357029) (CBMAB-P0904-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
V2-357029
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa 205-300 from human PAX9 (NP_006185) with GST tag.
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Paired Box 9
Introduction
PAX9 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3.
Entrez Gene ID
Human5083
Rat362741
UniProt ID
HumanP55771
RatQ2L4T2
Alternative Names
Paired Box 9; Paired Box Protein Pax-9; Paired Domain Gene 9; Paired Box Gene 9; STHAG3;
Function
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to growth factor stimulusIEA:Ensembl
Endoderm developmentIEA:Ensembl
Face morphogenesisIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
OdontogenesisIEA:Ensembl
Regulation of odontogenesisIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Tooth agenesis, selective, 3 (STHAG3):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
More Infomation

Hayashi, T., Kishi, M., Takamochi, K., Hosoya, M., Kohsaka, S., Kishikawa, S., ... & Tokyo Metropolitan Innovative Oncology Research Group (TMIG). (2023). Expression of paired box 9 defines an aggressive subset of lung adenocarcinoma preferentially occurring in smokers. Histopathology, 82(5), 672-683.

Chen, X., Li, Y., Paiboonrungruang, C., Li, Y., Peters, H., Kist, R., & Xiong, Z. (2022). PAX9 in cancer development. International Journal of Molecular Sciences, 23(10), 5589.

Zhao, Z., Szczepanski, A. P., Tsuboyama, N., Abdala-Valencia, H., Goo, Y. A., Singer, B. D., ... & Wang, L. (2021). PAX9 determines epigenetic state transition and cell fate in cancer. Cancer research, 81(18), 4696-4708.

Bhol, C. S., Patil, S., Sahu, B. B., Patra, S. K., & Bhutia, S. K. (2021). The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188561.

Sun, K., Yu, M., Yeh, I., Zhang, L., Liu, H., Cai, T., ... & Han, D. (2021). Functional study of novel PAX9 variants: The paired domain and non‐syndromic oligodontia. Oral Diseases, 27(6), 1468-1477.

Farley-Barnes, K. I., Deniz, E., Overton, M. M., Khokha, M. K., & Baserga, S. J. (2020). Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development. PLoS Genetics, 16(8), e1008967.

Xu, J., Zhang, Y., You, S., Guo, Y., Chen, S., Chang, Y., ... & Sun, Y. (2020). Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog. Life Sciences, 257, 118053.

Yang, C. W., Shi, J. Y., Yin, B., Shi, B., & Jia, Z. L. (2020). Mutation at Paired box gene 9 is associated with non-syndromic cleft lip only from Western Han Chinese population. Archives of Oral Biology, 117, 104829.

Li, R., Chen, Z., Yu, Q., Weng, M., & Chen, Z. (2019). The function and regulatory network of Pax9 gene in palate development. Journal of dental research, 98(3), 277-287.

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For research use only. Not intended for any clinical use.

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