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Mouse Anti-OXSR1 (AA 1-527) Recombinant Antibody (1B10) (CBMAB-O0805-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2a, Κ
Application
ELISA, IP, WB

Basic Information

Immunogen
OXSR1 (AAH08726.1, 1aa-527aa) full-length Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, Κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-527

Target

Full Name
Oxidative Stress Responsive 1
Introduction
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
Entrez Gene ID
9943
UniProt ID
O95747
Alternative Names
Oxidative Stress Responsive 1; Oxidative Stress-Responsive 1 Protein; EC 2.7.11.1; Osr1; Serine/Threonine-Protein Kinase OSR1; Oxidative-Stress Responsive 1; EC 2.7.11; KIAA1101
Function
Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764).
Phosphorylates PAK1 (PubMed:14707132).
Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).
Biological Process
Cellular hypotonic responseIEA:Ensembl
Cellular response to chemokineManual Assertion Based On ExperimentIMP:BHF-UCL
Chemokine (C-C motif) ligand 21 signaling pathwayBy SimilarityISS:BHF-UCL
Chemokine (C-X-C motif) ligand 12 signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of potassium ion transmembrane transporter activityIEA:Ensembl
Osmosensory signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of T cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
PTM
Autophosphorylated.
More Infomation

Li, P., Liu, Y., & You, T. (2023). CircNRIP1 knockdown alleviates Lipopolysaccharide-induced human kidney 2 cell apoptosis and inflammation through miR-339-5p/OXSR1 pathway. Shock, 59(3), 426-433.

Lei, C., Huo, Y., Ma, F., Liao, J., Hu, Z., Han, Q., ... & Tang, Z. (2023). Long-term copper exposure caused hepatocytes autophagy in broiler via miR-455-3p-OXSR1 axis. Chemico-Biological Interactions, 369, 110256.

Yang, Q., Sun, Q., & Jin, P. (2022). Long non‑coding RNA PVT1 regulates LPS‑induced acute kidney injury in an in vitro model of HK‑2 cells by modulating the miR‑27a‑3p/OXSR1 axis. Experimental and Therapeutic Medicine, 24(3), 1-10.

Chu, J., Geng, G., Ai, X., Jia, W., Wang, J., Xu, B., ... & Kong, L. (2022). LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis. The Journal of Gene Medicine, 24(2), e3394.

Cui, H., Ren, G., Hu, X., Xu, B., Li, Y., Niu, Z., & Mu, L. (2022). Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo. Renal Failure, 44(1), 1071-1083.

Wu, W., Zhong, W., Xu, Q., & Yan, J. (2022). Silencing of long non-coding RNA ZFAS1 alleviates LPS-induced acute lung injury by mediating the miR-96-5p/OXSR1 axis in sepsis. The American Journal of the Medical Sciences, 364(1), 66-75.

Li, H., Zhang, X., Wang, P., Zhou, X., Liang, H., & Li, C. (2021). Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury. Diabetology & metabolic syndrome, 13, 1-14.

Li, R., Wen, Y., Wu, B., He, M., Zhang, P., Zhang, Q., & Chen, Y. (2020). MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons. Biochemical and Biophysical Research Communications, 523(4), 859-866.

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For research use only. Not intended for any clinical use.

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