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Mouse Anti-ORC1 Antibody (1C4) (CBMAB-0771-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Fruit fly
Clone
1C4
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human, Fruit fly
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ORC1
Introduction
ORC1 (origin recognition complex, subunit 1) is the largest subunit of the ORC complex, the levels of which vary during the cell cycle. ORC1 has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication and is found to be selectively phosphorylated during mitosis.
Entrez Gene ID
Human4998
Fruit fly35686
UniProt ID
HumanQ13415
Fruit flyO16810
Alternative Names
HSORC1; ORC1L; PARC1
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Biological Process
DNA replication initiationManual Assertion Based On ExperimentIBA:GO_Central
Mitotic DNA replication checkpoint signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Meier-Gorlin syndrome 1 (MGORS1):
A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
PTM
A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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