Mouse Anti-OPRL1 Recombinant Antibody (2A11) (CBMAB-O0492-CQ)

Name: Mouse Anti-OPRL1 Recombinant Antibody (2A11)
SKU: CBMAB-O0492-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2A11

Antibody Isotype

IgG2a, Κ

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

opiate receptor-like 1

Introduction

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Entrez Gene ID

4987

UniProt ID

P41146

Alternative Names

Opioid Related Nociceptin Receptor 1; Orphanin FQ Receptor; Nociceptin/Orphanin FQ Receptor; Kappa3-Related Opioid Receptor; Kappa-Type 3 Opioid Receptor; Opiate Receptor-Like 1; KOR-3; ORL1

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Conditioned place preferenceIEA:Ensembl
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of cAMP-mediated signalingIEA:Ensembl
Negative regulation of voltage-gated calcium channel activityIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of gastric acid secretionIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Positive regulation of urine volumeIEA:Ensembl
Regulation of locomotor rhythmIEA:Ensembl
Response to estradiolIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentTAS:ProtInc
Sensory perception of painISS:UniProtKB

Cellular Location

Cell membrane
Cytoplasmic vesicle
Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Topology

Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-87
Helical: 88-109
Extracellular: 110-124
Helical: 125-146
Cytoplasmic: 147-165
Helical: 166-188
Extracellular: 189-211
Helical: 212-236
Cytoplasmic: 237-264
Helical: 265-285
Extracellular: 286-300
Helical: 301-322
Cytoplasmic: 323-370

PTM

Phosphorylation at Ser-363 requires GRK3.

More Infomation

References

Wang, X., Tao, Y., Zhang, C., Tian, J., & Yu, W. (2024). Expression heterogeneity, tumor immune characteristics and the prognosis effects of OPRL1 in patients with tumors: a pan-cancer study combined with bioinformation analyses and in vitro validation. Anesthesiology and Perioperative Science, 2(1), 1-16.

Ke, X., Huang, Y., Fu, Q., Majnik, A., Sampath, V., & Lane, R. H. (2023). Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus. The Anatomical Record, 306(1), 162-175.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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