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Mouse Anti-OMD (AA 21-421) Recombinant Antibody (CBXO-0396) (CBMAB-O0419-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0396
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
HEK293 human embryonic kidney cell line transfected with human Osteoadherin/OSAD, Gln21-Gln421, Accession # Q99983
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 21-421

Target

Full Name
osteomodulin
Introduction
OMD (Osteomodulin) is a Protein Coding gene. Diseases associated with OMD include Occult Macular Dystrophy and Hallermann-Streiff Syndrome. Among its related pathways are Defective CHST6 causes MCDC1 and Keratan sulfate/keratin metabolism. An important paralog of this gene is PRELP.
Entrez Gene ID
4958
UniProt ID
Q99983
Alternative Names
Osteomodulin; Keratan Sulfate Proteoglycan Osteomodulin; Osteoadherin Proteoglycan; KSPG Osteomodulin; SLRR2C; OSAD; Osteoadherin
Function
May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta3-integrin (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Regulation of bone mineralizationIEA:InterPro
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Binds keratan sulfate chains.
More Infomation

Zappia, J. (2023). Lack of osteomodulin is associated with skeletal development abnormalities and osteoarthritis.

Zappia, J., Tong, Q., Van der Cruyssen, R., Cornelis, F. M., Lambert, C., Pinto Coelho, T., ... & Henrotin, Y. (2023). Osteomodulin downregulation is associated with osteoarthritis development. Bone Research, 11(1), 49.

Tong, Q., Van der Cruyssen, R., Cornelis, F., Lambert, C., Coelho, T. P., Grisart, J., ... & Henrotin, Y. (2023). Osteomodulin down-regulation is associated with osteoarthritis development.

Li, Q., Chen, H., Liu, Y., & Bi, J. (2023). Osteomodulin contributes to keloid development by regulating p38 MAPK signaling. The Journal of Dermatology, 50(7), 895-905.

Skenteris, N. T., Seime, T., Witasp, A., Karlöf, E., Wasilewski, G. B., Heuschkel, M. A., ... & Matic, L. (2022). Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification. Clinical and Translational Medicine, 12(2), e682.

Gonçalves, I., Oduor, L., Matthes, F., Rakem, N., Meryn, J., Skenteris, N. T., ... & Bengtsson, E. (2022). Osteomodulin gene expression is associated with plaque calcification, stability, and fewer cardiovascular events in the CPIP Cohort. Stroke, 53(3), e79-e84.

Lin, W., Zhu, X., Gao, L., Mao, M., Gao, D., & Huang, Z. (2021). Osteomodulin positively regulates osteogenesis through interaction with BMP2. Cell Death & Disease, 12(2), 147.

Zappia, J., Van der Cruyssen, R., Sanchez, C., Lausberg, C., Lambert, C., Florin, A., ... & Henrotin, Y. (2021). Osteomodulin impacts positively the bone remodeling process in osteoarthritis. Osteoarthritis and Cartilage, 29, S111.

Skenteris, N. T., Seime, T., Witasp, A., Karlöf, E., Wasilewski, G., Chartou, M., ... & Matic, L. (2021). Osteomodulin is a novel gene in cardiovascular calcification. Atherosclerosis, 331, e93.

Lin, W., Gao, L., Jiang, W., Niu, C., Yuan, K., Hu, X., ... & Huang, Z. (2019). The role of osteomodulin on osteo/odontogenic differentiation in human dental pulp stem cells. BMC Oral Health, 19, 1-8.

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For research use only. Not intended for any clinical use.

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